How to Contribute to STAT’s First Opinion: A Letter to the Editor Guide

Overview

STAT’s First Opinion section is a dedicated space for thought-provoking essays on the life sciences, penned by industry insiders, healthcare professionals, and researchers. These articles spark discussion, and to foster a robust exchange of ideas, STAT publishes selected Letters to the Editor in response. This guide walks you through the process of crafting and submitting a letter that stands out—whether you’re a scientist, clinician, patient advocate, or simply an engaged reader. By the end, you’ll know how to turn your reaction into a polished, publishable piece.

Letters to the Editor are brief, focused responses that challenge, expand on, or clarify points raised in a First Opinion essay. They’re a powerful way to join the conversation, influence ongoing debates, and get your voice heard by a wide audience of life science professionals.

Prerequisites

Before you start writing, make sure you have the following:

• A recent First Opinion essay – Read one that resonates with you. Access them for free on STAT’s website.
• A clear, concise viewpoint – Your letter should add value, not just agree or disagree. Identify a specific claim, data point, or perspective you want to address.
• Time for revision – Polishing your letter increases its chances of selection.
• Submission access – You can submit via the form at the end of any First Opinion essay, or directly via the letter submission page.

Step-by-Step Instructions

Step 1: Read and React Strategically

Choose an essay that sparks a strong, thoughtful reaction. As you read, highlight points you want to challenge or support. Consider:

• Does the essay overlook a key perspective?
• Is there a factual error worth correcting?
• Can you offer personal experience or data that deepens the discussion?

Your reaction should be specific—avoid broad, general praise or criticism.

Step 2: Draft Your Letter

Keep your letter between 200–300 words (STAT prefers brevity). Structure it as follows:

1. Opening – Refer directly to the essay by title and author. Example: “In her recent First Opinion essay, ‘The Cost of Innovation,’ Dr. Jane Doe argues that… While I agree on the need for funding, I’d add that community-based solutions are equally vital.”
2. Body – Present your point with evidence. Use data, anecdotes, or logical reasoning. For example: “A 2023 study in Health Affairs shows that community clinics reduce costs by 20%—a factor Doe doesn’t mention.”
3. Conclusion – End with a constructive call to action or a provocative question that invites further thought. Avoid personal attacks or emotional rants.

Write in a professional yet engaging tone. Use bold for key terms and italic for publication titles, but sparingly.

Step 3: Revise and Refine

Edit for clarity, conciseness, and impact. Check for:

• Factual accuracy – Verify any statistics or references.
• Politeness – Even when disagreeing, maintain a respectful tone.
• Relevance – Every sentence should tie back to the essay.

Read your draft aloud—if it sounds unnatural, rewrite it.

Step 4: Submit Properly

Go to the submission form at the end of the First Opinion essay or use STAT’s dedicated letter portal. Fill in your name, email, affiliation (if applicable), and paste your letter. Include a brief bio if relevant (e.g., “John Smith is a practicing oncologist in Seattle”).

Double-check that your letter includes the essay title and author—editors need to match it.

Step 5: Wait and Follow Up

STAT receives many letters; only selected ones are published. If you don’t hear back within two weeks, you may send a polite follow-up email via the same form. However, avoid sending multiple submissions on the same topic.

Common Mistakes to Avoid

• Being too vague – “I disagree with the article” is not enough. Specify what and why.
• Exceeding length – Over 400 words are rarely considered. Stick to the 300-word target.
• Ignoring the essay’s core argument – Stay focused; don’t pivot to unrelated grievances.
• Using hostile language – Personal attacks undermine credibility. Stick to ideas.
• Failing to include context – Assume the editor hasn’t read the essay recently; remind them of key points.
• Submitting too late – Respond within a week of publication while the essay is still fresh.
• Forgetting contact info – Without a verifiable email, your letter may be discarded.

Summary

Writing a letter to the editor for STAT’s First Opinion is your opportunity to engage with leading voices in life sciences. Start by selecting an essay that moves you, craft a concise, evidence-based response, and follow submission guidelines carefully. Avoid common pitfalls like vagueness or animosity. With these steps, your letter has a strong chance of joining the public dialogue. Ready to contribute? Read a First Opinion essay today and share your insight.